Author

Ruheng Wang

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Oct 2026

Interpretable Protein−Nucleic Acid Binding Site Prediction via Domain-Guided Multimodal Learning

Accurate identification of protein−nucleic acid binding sites is essential for elucidating molecular mechanisms and for enabling structure-based drug discovery. Existing computational approaches struggle to jointly model sequence, structure, and domain knowledge, which limits both predictive accuracy and interpretabi...

Wen-Yu Xi, Ru-Heng Wang, Xiu-Cai Ye et al. · ACS Synthetic Biology · 0 citations

Open access Aug 2026

NanoPrism: A Taxonomy-Guided Pipeline for Rapid Functional Profiling of Oxford Nanopore Long-Read Metagenomes

Background/Objectives: Oxford Nanopore sequencing produces long reads quickly, but most functional profiling tools were developed for short reads or rely on assembly pipelines that are computationally costly and sensitive to long-read error rates. We present NanoPrism, a taxonomy-guided pipeline for rapid functional pr...

Jiwoong Kim, Shuheng Gan, Harish Jawahar et al. · DNA · 0 citations

Sep 2026

Deciphering T-cell receptor-antigen recognition through interpretable residue-level interaction modeling.

Accurate identification of interactions between T-cell receptors (TCRs) and antigenic peptides presented by major histocompatibility complex (MHC) molecules is essential for advancing precision immunotherapy. However, existing approaches often exhibit limited generalization to unseen peptides and struggle to capture th...

Wen-Yu Xi, Ru-Heng Wang, Xiu-Cai Ye et al. · International Journal of Bio... · 0 citations