Review
Open access
Sep 2026
Cuproptosis in Cerebrovascular Diseases: Mechanisms and Advances in Targeted Therapeutic Strategies.
Cuproptosis is a recently identified form of regulated cell death. It is primarily driven by abnormal mitochondrial copper accumulation. Ferredoxin 1-dependent copper reduction promotes the pathological aggregation of lipoylated proteins involved in the tricarboxylic acid cycle and the loss of iron-sulfur cluster prote...
Xin-Yi Zhang, Ru-Fan Xu, Hong-Rui Zhang et al.
· Brain Research Bulletin · 0 citations