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Review Open access Oct 2026

Therapeutic Potential of Marine Natural Products Against Alzheimer’s Disease: Molecular Mechanisms, Druggability Evaluation and Clinical Translation Barriers

Alzheimer’s disease (AD) is an irreversible neurodegenerative disorder with complex multifactorial pathological cascades, including amyloid-β (Aβ) aggregation, tau hyperphosphorylation, sustained neuroinflammation, oxidative stress, cholinergic dysfunction and gut–brain axis imbalance. Current marketed anti-AD drugs me...

Dao-Wei Huang, Rou-Jun Lu, Chen-Chen Sheng et al. · 0 citations
Review Aug 2026

Overcoming the blood-brain barrier for therapeutics targeting neurodegenerative diseases: a patent review (2020-present).

INTRODUCTION The blood-brain barrier (BBB) restricts drug entry into the CNS, with most therapeutics showing < 1% brain penetration, limiting efficacy in neurodegenerative diseases. AREAS COVERED Patents (2020-2026) were retrieved from SciFinder, Web of Science, PubMed, and Reaxys using combinations of 'blood-brain b...

Daowei Huang, Roujun Lu, Rui-Jing Tang et al. · 0 citations

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