Open access
Aug 2026
GNL3 SUMOylation is essential for DNA double-strand break repair by homologous recombination
DNA double-strand break repair via homologous recombination is critical for maintaining genomic integrity and requires proper DNA end resection. Here, we identify GNL3, a nucleolar GTP-binding protein, as a key regulator of homologous recombination in human cells via SUMOylation-dependent control of DNA end resection....
Yun-Han Yang, Yan-Ping Li, Roselyn S. Dai et al.
· Nature Communications · 0 citations