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Rong-Zhen Tian

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#protein folding Oct 2026

Constructing nucleoside deaminase-assisted orthogonal DNA replication system for continuous evolution in prokaryotes.

Orthogonal DNA replication system-based continuous evolution enables user-defined genes to undergo a hypermutagenic evolutionary state through a replication process independent of the host genome, while maintaining overall cellular stability. However, its application is constrained by the relatively low mutation rate o...

Wei-Ran Chu, Rong-Zhen Tian, Ya-Xin Guo et al. · 0 citations

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