Rong Zhang

Thirteen‐year genomic analysis (2010–2022) reveals high‐risk ICU Pseudomonas aeruginosa in China

Abstract Pseudomonas aeruginosa is a significant opportunistic pathogen, particularly prevalent in intensive care units (ICUs). Through a comprehensive genomic and phenotypic analysis of 518 ICU and healthy isolates collected over a 13‐year period (2010–2022), we found that ICU strains, despite reduced sequence type (S...

"One Health"-based epidemiological investigation reveals the emergence of carbapenem-resistant Morganella spp. across diverse ecological niches.

OBJECTIVES To investigate the prevalence, genomic relatedness, and resistance characteristics of carbapenemase-gene-positive Morganella spp. (CRM) across human, animal, fly, and aquatic sources. METHODS A total of 163 Morganella isolates were collected from humans (n=124), animals (n=5), flies (n=21), aquatic environ...

Pre-existing antibiotic tolerance facilitates plasmid-mediated carbapenem resistance evolution in clinical Klebsiella pneumoniae