Poly(l-glutamic Acid)-Based Microgels with Long-Term Synergistic Lubrication and MMP-Responsive Anti-Inflammatory Delivery for Osteoarthritis Therapy.
Osteoarthritis (OA) is a degenerative joint disease characterized by the failure of cartilage lubrication and persistent inflammation induced by friction-generated debris. Therefore, an effective OA treatment strategy should simultaneously enhance joint long-term lubrication and suppress inflammation. Toward this goal,...