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Author

Rong-Rong Liu

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Open access Aug 2026

Autophagic flux inhibition potentiates disulfidptosis susceptibility in human hepatocellular carcinoma

Disulfidptosis is a newly recognized form of non-classical cell death, characterized by the abnormal accumulation of disulfide bonds and the collapse of the cytoskeleton. Nevertheless, the regulatory mechanisms governing this process are not fully understood. Although autophagy is a crucial cellular process necessary...

Meng-Jiao Shi, Liang-Wen Yan, Kai-Ling Hu et al. · 0 citations
Sep 2026

Kuwanon E sensitizes hepatocellular carcinoma cells to disulfidptosis via MTOR-mediated autophagy blockade.

Kuwanon E (KE) is identified as the most potent sensitizer of disulfidptosis in HCC cells and is established as a functional disulfidptosis-sensitizing agent from a natural source, providing a compelling mechanistic rationale for targeting disulfidptosis to overcome metabolic and autophagic resistance in HCC.

Xin-Yan Li, Liang-Wen Yan, Kai-Ling Hu et al. · 0 citations

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