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Oct 2026

Converting Nonspecific Adsorption into Bioaffinity Recognition: Defect-Engineered MOF-808 Creates a Synergistic Enzyme Interface for Selective Ligand Fishing and Closed-Loop Target Confirmation

Nonspecific adsorption of metal −organic frameworks (MOFs) limits the analytical reliability of immobilized-enzyme ligand fishing in complex natural systems. In this work, an activity-guided defect-engineering strategy was developed to convert MOF-808 into a synergistic enzyme-MOF biointerface for selective molecular...

Wei Zhao, Xiao-Jing Liang, Qi-Hui Sun et al. · 0 citations
Aug 2026

Dihydroorotate Dehydrogenase Inhibitors are Potent Antiviral Agents against Henipaviruses and Arenaviruses.

Hendra virus (HeV) and Nipah virus (NiV) are zoonotic henipaviruses associated with high mortality and are classified as Biosafety Level 4 (BSL-4) agents. To identify small molecule inhibitors, we performed a cell-based high-throughput screening (HTS) of an antiviral compound library using recombinant Cedar virus (rCed...

Yuanyuan Li, Jing Ma, Ryan Bott et al. · 0 citations

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