Author

Rong-Quan He

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Open access Aug 2026

CRISPR Screen Reveals Pathways and Factors Driving Tyrosine Kinase Inhibitor Resistance in Hepatocellular Carcinoma

This study identified GPATCH4, CCT3, C19orf53, UACA, PPM1M, and LIN37 as key genes mediating TKI resistance in HCC, and identified Ferroptosis, epithelial‐mesenchymal transition and hypoxia were new research directions, which were closely related to the pathways investigated in this study.

Siyi Chen, Li-Hua Yang, Zi-Qian Liang et al. · Cancer Medicine · 0 citations

Open access Jan 2026

A Potential miR‐1246‐5p–H3K27ac–NOL12 Regulatory Axis and Its Putative Tumour‐Promoting Function in Hepatocellular Carcinoma

NOL12 may be regulated by the putative miR‐1246‐5p/H3K27ac enhancer axis and promotes HCC progression through the spliceosome pathway, supporting its potential as a novel therapeutic target for HCC.

Li Xiao, Yu-Long Deng, Li-Na Liang et al. · IET Systems Biology · 0 citations

Open access Aug 2026

Clinical validation of KIF11 overexpression in colorectal cancer and its potential association with the antitumor effects of nitidine chloride

In vitro and limited xenograft data indicate that NC restrains CRC growth chiefly through the RAD21–KIF11 axis; KIF11 represents a promising preclinical target, though comprehensive systematic in vivo pharmacodynamic and translational animal validation remains absent in the current study and requires further independen...

Hui Li, Rui Lin, Ke-Jun Wu et al. · Hereditas · 0 citations