MHC restriction — the requirement for αβ T cell receptors (TCRs) to recognize Major Histocompatibility Complex (MHC) molecules when presenting peptide antigens — is a pillar of adaptive immunity. Here, we provide direct structural evidence for TCR germline-encoded recognition of MHC molecules irrespective of antigenic...
Nan Wang, Marta T. Borowska, K. Jude et al.· bioRxiv· 0 citations
It is revealed that CD16a transduces piconewton forces and acts as a mechanosensor to facilitate NK activation, and it is demonstrated that CD16a force and the actin foci formation associated with it are essential for the phosphorylation of mechanosensitive adaptor Cas-L and signaling adaptor LAT, reshaping NK cell cyt...
Rong Ma, K. Garcia, Bian-Xiao Cui et al.· Science Advances· 0 citations
Natural Killer(NK) cells eliminate target cells through antibody-dependent cell-mediated cytotoxicity(ADCC), initiated by CD16a(FcγRIIIa) recognizing the Fc region of antibodies bound to the target cell surface. While the recognition is considered to be driven by CD16a-Fc binding avidity, it fails to explain why Fc mul...
Rong Ma, K. Garcia, Bian-Xiao Cui et al.· bioRxiv· 0 citations
The LINC-seq platform, LINC-seq, recovered known cognate pairs from pooled libraries at up to 95% accuracy and performed simultaneous, library-on-library deep mutational scanning of both partners, and generalizes to any receptor-ligand pair whose trans-engagement drives a reporter.
L. Liu, Seung Won Shin, Kevin M. Joslin et al.· bioRxiv· 0 citations
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