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Author

Ronghao Tang

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Sep 2026

A TMEM119-tankyrase axis restrains microglial phagocytosis to maintain memory and enables pharmacological forgetting.

The persistence or loss of memory depends on the stability of synaptic connections. Microglia regulate this stability in part by phagocytic elimination of synapses, while the molecular mechanism that sets their intrinsic phagocytic capacity at homeostasis remains unknown. Here, we show that TMEM119, a microglia-specifi...

Su-Hua Sun, Chen-Feng Wang, Yang Bian et al. · 0 citations
Open access Aug 2026

RPL41 stabilizes ribosome dynamics and supports long-protein homeostasis in mammals

Cryo-electron microscopy reveals a conserved role for RPL41 in maintaining ribosome dynamics and translational fidelity, indicating that RPL41 supports ribosome function and long-protein homeostasis in mammals.

Mina Hirata, Maho Fujino, Kazuya Ichihara et al. · 0 citations

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