Potency of nucleoside analogs against Powassan virus replication and identification of 4′-fluorouridine as a therapeutic candidate for tick-borne orthoflavivirus encephalitis
Powassan virus (POWV) is an emerging tick-borne orthoflavivirus that causes severe encephalitis, long-term neurologic sequelae, and death, yet no approved antiviral therapies exist. Here, we evaluated several previously characterized nucleoside analogs as candidate countermeasures for POWV encephalitis. Favipiravir, mo...