Author

Rolf Müller

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Open access Oct 2026

Design, Synthesis, and Preliminary Investigation on the Mode of Action for a Series of Novel Antimicrobial Peptidomimetics

Over the years, many antibiotics have been developed, but most have become less effective due to antimicrobial resistance, especially those targeting enzymatic pathways. This growing resistance poses a serious global health threat. It is now recognized that physically disrupting bacterial cell membranes is less prone...

Diletta Bergamo, Katarina Cirnski, Mathias Müsken et al. · Journal of Medicinal Chemist... · 0 citations

Open access Aug 2026

Discovery and Biosynthetic Characterization of Darumycins Expand the Chemical Space of Sesterterpene Antibiotics

The discovery and characterization of darumycins, guanidine-containing pentacyclic sesterterpene antibiotics that exhibit potent activity against high-priority Gram-positive pathogens and mycobacteria are reported.

Dmytro Bratiichuk, Dominik Kolling, Irma Redzic et al. · JACS Au · 0 citations

Open access Aug 2026

Atypical Condensation Domains Guide Discovery and Illuminate Biosynthesis of Myxoglucamides Featuring Vinyl-Substituted, α-Oxidized γ-Amino Acids.

Condensation (C) domains in nonribosomal peptide synthetase (NRPS) pathways exhibit versatile functions that drive biosynthetic and chemical novelty. Through genome mining for atypical C domains, we identified a hybrid NRPS/polyketide synthase (PKS) biosynthetic gene cluster (mxg) from Cystobacterineae sp. MCy9003 and...

Tingting Wang, Alexander Popoff, Maja Hunter et al. · Angewandte Chemie · 2 citations