Author

Rohit Kumar Singh

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Review Oct 2026

Beyond Histamine Blockade: Clemastine Fumarate as a Promoter of Myelin Regeneration, Inflammatory Regulation, and Neuroimmune Modulation in CNS Disorders

Rohit Kumar Singh, Chandrayee Banerjee, Sidharth Mehan · Journal of Neuroimmune Pharm... · 0 citations

Review Jan 2026

GPCR-Driven Muscarinic M1 and Histamine H1 Receptor Signaling Converging on the PI3K/Akt/mTOR Pathway: Functional Integration in Neuroinflammation and Myelin Repair in Multiple Sclerosis

This review comprehensively examines the interconnected roles of the CHRM1, H1R, and the PI3K/Akt/mTOR signaling pathway in MS pathophysiology and highlights the functional cross-talk between cholinergic and histaminergic signaling and their convergence on PI3K/Akt/mTOR-mediated cellular responses.

Rohit Kumar Singh, Janvi Verma, Sidharth Mehan et al. · Molecular Neurobiology · 0 citations

Review Aug 2026

Pentadecanoic Acid as a Potential Endogenous mTOR Modulator for Age-Related Female Infertility: Mechanistic Insights, Molecular Docking Evidence, and Therapeutic Perspectives.

R. Kalfin, Sidharth Mehan, Rajaram Samant et al. · Journal of Steroid Biochemis... · 0 citations

Aug 2026

Combined clemastine fumarate and selenomethionine promote remyelination via PI3K/Akt/mTOR signaling in experimental multiple sclerosis.

CMF and SLM appear to exert complementary neuroprotective and remyelinating effects, CMF principally promoting oligodendrocyte-mediated remyelination and SLM limiting oxidative and inflammatory injury that together converge on the PI3K/Akt/mTOR axis, supporting simultaneous dual-target intervention as a rational strate...

Rohit Kumar Singh, Sidharth Mehan · Naunyn-Schmiedeberg's Archiv... · 0 citations