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Robert Wieczorek

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Open access Sep 2026

Preparation of Deuterium-Labeled Tadalafil and Omeprazole by Carbon Hydrogen-Deuterium Exchange: Hydrogen Scrambling, Acid-Induced Transformation, and LC-MS Applications.

RATIONALE Stable isotope-labeled compounds are indispensable internal standards for reliable liquid chromatography-mass spectrometry (LC-MS) analysis, but their preparation frequently requires multistep synthesis. Base-catalyzed hydrogen-deuterium exchange at carbon centers provides a simple alternative for generating...

Martyna Hofman-Kotyla, Paulina Grocholska-Zamiara, Robert Wieczorek et al. · 0 citations

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