Open access
Jul 2026
Adeno-associated Virus (AAV) Synthetic Inverted Terminal Repeat Enhances Tissue Specific Transduction and Altered Vector Induced Stress Response
Data demonstrate that SynITRs elicit tissue-specific transduction enhancement and alter the cellular stress response and offer an alternative context to elucidate wtITR biology for targeted, enhanced, and potentially safer human gene therapy.
Tomoko Hasegawa, Naveen Vridhachalam, Ethan Sud Nikolai et al.
· bioRxiv · 0 citations