Author

Robert L. Eil

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Sep 2026

Tumor-derived antioxidants suppress immunity by depriving T cells of reactive oxygen species.

Reactive oxygen species (ROS) promote genomic instability and fuel oncogenic signaling in cancer, but antioxidant therapies have so far failed to improve, or worsen, cancer outcomes. Emerging data suggest that T cells depend on ROS for signal transduction. In this study, we show that tumors exploit this dependency, rel...

Alexander J. Wesolowski, Ardon M. Pillay, Panagiota Vardaka et al. · Science · 1 citation

Sep 2026

The post-transcriptional regulator HuR promotes immune evasion in pancreatic ductal adenocarcinoma.

Overall, it is found that the post-transcriptional regulator HuR facilitates immune evasion in PDAC by constraining T-cell function, identifying HuR blockade as a promising therapeutic strategy in combination with immunotherapies.

Yi-Fei Guo, Jennifer M. Finan, Alexandra Q. Bartlett et al. · Cancer immunology research · 0 citations