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Author

Robert J. Davidson

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Open access Jul 2026

Factor VIII Aurora: A Naturally Occurring Gain of Function FVIII Variant with Enhanced FIXa Affinity.

Data demonstrate that the prothrombotic phenotype of FVIII-R571S is driven by increased FIXa affinity, which enhances FVIIIa-FIXa complex assembly and function, providing a unifying explanation for the observed gain-of-function phenotype.

Johnathan J Morris, Robert J. Davidson, Connor T Watson et al. · 0 citations

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