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Robert J. Chalkley

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Open access Oct 2026

Optimization of Search and Acquisition Strategies for DSSO Crosslinking Mass Spectrometry using Protein Prospector and Touchstone

A new capability within the Protein Prospector search engine is implemented to improve MS2-based identification of MS-cleavable cross-linked peptides and Touchstone, a framework for re-scoring, classification, FDR-controlled summarization, and visualization of Prospector XL-MS search results are developed.

M. Trnka, Clinton Yu, Peter R. Baker et al. · 0 citations

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