Open access
Sep 2026
Gut microbiome and metabolite profiles are associated with subsequent histologic MASH in a longitudinal mouse model
ABSTRACT Detecting metabolic dysfunction-associated steatohepatitis (MASH) before fibrosis develops remains a major challenge. We used a longitudinal streptozotocin/high-fat diet (STAM/HFD) mouse model to identify microbial and metabolic features that emerge before histological MASH onset. Integrative 16S rRNA and unta...
Stephany Flores Ramos, Kelly A. Fogelson, V. Muti et al.
· mSystems · 0 citations