Open access
Aug 2026
The Wobble Uridine tRNA Writer MnmA Shapes Codon-Dependent Stress Response Systems
Escherichia coli uses wobble uridine (U34) modifications to tune codon decoding, but how individual tRNA writer enzymes shape gene expression remains unclear. Here, we identify MnmA, the U34 thiolation enzyme for tRNALys, tRNAGln, and tRNAGlu, as a central regulator linking codon-directed translation to regulon control...
H. Omeoga, Dylan J. Ehrbar, Chetna Mathur et al.
· bioRxiv · 0 citations