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Author

Rithu K. Pattali

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Open access Oct 2026

Cell-type-specific repression reveals MC4R neurons as a site of action for ciliary obesity genes.

OBJECTIVES Understanding how obesity-associated genes function within defined neuronal subpopulations remains a major barrier to translating human genetics into pathophysiological mechanisms. Melanocortin-4 receptor-expressing (MC4R) neurons are key regulators of energy homeostasis and represent a potential site of act...

Abbey Diener Blake, Zhi-Xuan Zhang, Coralie Alexandre et al. · 0 citations
Open access Jul 2026

Programmable CRISPRtune dissects the transcriptional repressive activity of MeCP2

A programmable method for transcriptional tuning in mammalian cells is presented and an orthogonal platform to dissect the mechanistic function of chromatin regulators in living cells is offered.

Jinna I. Brim, Izaiah J. Ornelas, Peter J. Colias et al. · 0 citations

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