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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Risako Miura

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2 papers indexed here

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Sep 2026

Discovery of Novel Oral Covalent Inhibitors Targeting Active GTP-Bound KRASG12C with Potent Antitumor Activity

Current KRASG12C inhibitors mainly target the inactive GDP-bound state, but clinical efficacy is limited, and resistance mechanisms have been identified. We disclose novel covalent inhibitors that selectively target the active GTP-bound KRASG12C. Starting from a high-throughput screen, we identified a keto-indolizine...

Juan del Pozo, Elisabeth T. Hennessy, Patrick Schoepf et al. · 0 citations
Open access Aug 2026

Development and In Vitro Evaluation of Near-Infrared Dye-Conjugated Pullulan-Based Nanogels for M2 Macrophage-Targeted pH-Responsive Theranostic Agents

Immunotherapy can reduce treatment-related side effects but shows limited efficacy in “cold tumors,” whose immunosuppressive tumor immune microenvironment is characterized by abundant M2 macrophages and poor T cell infiltration. Because biopsy-based qualitative assessment of the tumor microenvironment is invasive and c...

Risako Miura, Mahiro Kagami, Yu Kimura et al. · 0 citations

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