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Richard Southworth

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Open access Sep 2026

Beyond glucose: metabolic substrate provision enhances cardiac energetics, function and stability ex vivo: a simple recipe for healthier hearts?

AIMS In 1932, Hans Krebs and Kurt Henseleit introduced a bicarbonate-based solution for liver perfusion containing only 5.55 mM glucose. This bicarbonate-based Krebs-Henseleit buffer (KHB) has been frequently modified over many years but typically includes only glucose as a substrate, often to hyperglycaemic levels. Ho...

Zoe Hoare, Yu-Jin Chung, E. Waters et al. · 0 citations

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