Author

Richard P. Koche

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Open access Sep 2026

Mitochondrial ATP promotes T cell differentiation through chromatin accessibility.

Immune elimination of chronic infection or cancer requires cytotoxic CD8+ T cells that adopt and maintain an effector phenotype. Cytotoxic T cell function is a bioenergetically demanding process. Here, we report the ability of D-α-hydroxybutyrate (DAHB) to act as a signaling molecule that increases mitochondrial ATP pr...

Charles Ng, Tak-Shun Fung, Da-Yi Li et al. · Cell · 0 citations

Sep 2026

Abstract B009: DNA-proximal MYB phosphorylation is required for oncogenic transcription in acute myeloid leukemia

DNA-proximal phosphorylation of MYB is identified as a critical regulatory mechanism required for MYB oncogenesis through cooperative organization of transcription factors and nominated MYB N-terminal phosphorylation and its upstream kinases as candidate therapeutic targets for MYB-dependent leukemia.

Shu-Yuan Cheng, Katarzyna Kulej, Masahiro Uni et al. · Cancer Research · 0 citations