Type 1 diabetes (T1D) risk variants within SIRPG influence transcript splicing and alter the expression of signal regulatory protein gamma (SIRPγ) on human T cells; however, the functional consequences of the risk variants remain poorly defined. Here, we demonstrate that peripheral blood mononuclear cells from individu...
Robert C. Sharp, Matthew E. Brown, Leeana D. Peters et al.· npj Autoimmunity· 0 citations
Effector CD8+ T cells are key drivers of type 1 diabetes (T1D) pathogenesis, yet questions remain regarding the molecular defects leading to altered cytotoxicity, peripheral tissue phenotype, and receptor specificity. We analyzed human pancreatic lymph nodes (pLNs) using mass cytometry and single-cell RNA-seq (scRNA-se...
Leeana D. Peters, Howard R. Seay, Justin A. Smith et al.· Journal of Clinical Investig...· 1 citation
The Bootstrap-Enhanced Regularization Method (BERM) is a robust approach for variable selection and coefficient estimation in complex biomedical datasets, achieving the highest overall balanced accuracy while maintaining competitive coefficient estimation performance across a range of simulated sparsity, noise, and dim...
GenesetGPT is proposed, an efficient, LLM-based framework that emphasizes both curated biological context and iterative prompt construction, thus enabling realistic summarization of heterogeneous gene sets at scale.
Jack R. Leary, Samantha Pattey, Rhonda L. Bacher· bioRxiv· 0 citations
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