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Author

René Hen

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Open access Oct 2026

Effects of prucalopride on anxiety and depressive symptoms among constipated patients: A meta-analysis of randomized controlled trials.

AIMS Prucalopride, a 5-HT4 receptor agonist, has shown potential for rapid anxiolytic and antidepressant effects in preclinical studies. This meta-analysis aims to evaluate changes in anxiety and depressive symptoms after prucalopride treatment in chronically constipated adults. METHODS A systematic search of PubMed,...

Lucie Lebon, Denis J. David, M. Gasnier et al. · 0 citations
Open access Aug 2026

Dysregulated adult hippocampal neurogenesis in major depressive disorders.

A neurogenic lineage in the adult human hippocampal subgranular zone is identified and evidence for a stalled neurogenic process in MDD is provided, associated with transcriptional regulation, stress-related reprogramming and interferon signaling across developmental stages.

Madeleine S Peng, Jia-Jia Jiang, Luciana Polizzi et al. · 2 citations

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