Oct 2026
Orai3 deficiency drives atrial remodeling and fibrillation susceptibility via Orai channel remodeling and SOCE hyperactivation.
AIMS Atrial remodeling is the pathological substrate for atrial fibrillation (AF), yet no targeted therapies exist. The Orai3 calcium channel regulates cardiac homeostasis, but its role in atrial remodeling remains unexplored. METHODS Wild type and Orai3 knockout rats were subjected to Angiotensin II infusion or acet...
Xiao-He Wu, Yang-Cheng Xue, Hao-Yang Lu et al.
· Life Science · 0 citations