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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

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Ren-Shuai Liu

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Review Open access Aug 2026

Covalent warheads as a versatile platform for molecular glue development.

Targeted protein degradation (TPD) has become a novel therapeutic modality for diseases in drug discovery. Most progress on TPD has focused on the ubiquitin proteasome system; however, only a handful of >600 human genome-encoded E3 ligases have been successfully applied. Expansion of the E3 ligase toolbox with novel E3...

Bo Zhang, Shi-Ji Zhang, Ren-Shuai Liu et al. · 0 citations

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