Open access
Sep 2026
Preparation of Deuterium-Labeled Tadalafil and Omeprazole by Carbon Hydrogen-Deuterium Exchange: Hydrogen Scrambling, Acid-Induced Transformation, and LC-MS Applications.
RATIONALE Stable isotope-labeled compounds are indispensable internal standards for reliable liquid chromatography-mass spectrometry (LC-MS) analysis, but their preparation frequently requires multistep synthesis. Base-catalyzed hydrogen-deuterium exchange at carbon centers provides a simple alternative for generating...
Martyna Hofman-Kotyla, Paulina Grocholska-Zamiara, Robert Wieczorek et al.
· Rapid Communications in Mass... · 0 citations