Author

Rekha Sathian

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Open access Sep 2026

Loss of novel mechanosensitive ion channel TMEM63A impairs osteogenic differentiation and proliferation via disruption of cellular mechanotransduction

Skeletal homeostasis depends critically on the local mechanobiological microenvironment. While well-known mechanosensitive ion channels like Piezo1 and Piezo2 translate physical forces into immediate membrane ion fluxes, the proximal sensors regulating medium- and long-term osteogenic pathways remain poorly understood....

Meghana Davuluri, Rekha Sathian, Anna R. Cho et al. · Mechanobiology in medicine · 0 citations

#artificial intelligence Preprint Oct 2026

Unlocking the Regulatory Genome by ARGUS: An Evidence-Constrained Agentic Framework for Interpreting Single Nucleotide Variants

Over 90% of disease-associated variants from genome-wide association studies fall in noncoding regulatory regions, yet their functional interpretation remains a central open problem in genomic medicine. Large language models prompted to interpret such variants routinely hallucinate transcription factor (TF) binding cha...

P. Dutta, Matthew B. Obusan, Max Chao et al. · 0 citations

Open access Sep 2026

Genomic language model for predicting enhancers and their allele-specific activity in the human genome

It is shown that genome-wide enhancer annotations and candidate genetic variants predicted by DNABERT-Enhancer provide valuable resources for genome interpretation in functional and clinical genomics studies and can be explored interactively via the web application.

Rekha Sathian, P. Dutta, Ferhat Ay et al. · Bioinformatics · 0 citations