Author

Reinhard Fässler

2 papers indexed here

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Aug 2026

Single-Molecule Force Spectroscopy Reveals a High-Force Requirement for Dissociation of Integrin Transmembrane Domains.

Integrins are bidirectional mechanochemical receptors that transmit signals upon ligand binding to the cytoskeleton (outside-in) and cytoskeletal forces back across the membrane (inside-out) to the integrin-ligand bond. Integrins are activated prior to ligand binding, which involves large conformational rearrangements...

Mandana Christine Hadawi, Bin Li, Monja Fink et al. · Biophysical Journal · 0 citations

Open access Aug 2026

Load-dependent RGD-context sensing via αV-class integrins reprograms cell adhesion and mechanics

The biochemical and mechanical properties of extracellular matrix proteins govern cell adhesion, mechanics, and migration. How cells use integrins to discriminate between the arginine-glycine-aspartic acid motifs presented by different extracellular matrix proteins, a process central to tissue homeostasis and disease,...

Upnishad Sharma, Jakob M. Reber, J. Helenius et al. · Nature Communications · 0 citations