Rebecca S. Kaufman

Abstract C008: Expanding the spectrum of pathogenic germline BARD1 variants in children with neuroblastoma

Pathogenic germline variants in BARD1 are strongly associated with neuroblastoma, and emerging evidence from our group and others suggests that heterozygous loss-of-function BARD1 variants may confer sensitivity to PARP inhibition, analogous to BRCA1-deficient cancers. This potential therapeutic vulnerability undersc...