EXPRESS: Synaptic density PET mediates the relationship between Alzheimer's disease pathology and cognitive performance.
INTRODUCTION Synaptic loss is one of the strongest post-mortem predictors of Alzheimer's disease (AD) severity and may impact how pathology affects cognition. This study compared regional [11C]UCB-J synaptic density across the AD continuum and evaluated the extent to which synaptic density mediates relationships betwee...