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Author

Rebecca E. Langhough

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Oct 2026

EXPRESS: Synaptic density PET mediates the relationship between Alzheimer's disease pathology and cognitive performance.

INTRODUCTION Synaptic loss is one of the strongest post-mortem predictors of Alzheimer's disease (AD) severity and may impact how pathology affects cognition. This study compared regional [11C]UCB-J synaptic density across the AD continuum and evaluated the extent to which synaptic density mediates relationships betwee...

Max J. McLachlan, Brecca Bettcher, Rebecca E. Langhough et al. · 0 citations
Open access Aug 2026

Neurobiological correlates of longitudinal grey matter volume changes in preclinical Alzheimer’s disease

In this large longitudinal sample of asymptomatic individuals, the Aβ-dominant biomarker component showed the strongest association with longitudinal GM atrophy and cognitive decline, beyond the effects of tau pathophysiology and neuroaxonal injury.

W. Pelkmans, R. Cacciaglia, Michalis Kassinopoulos et al. · 0 citations

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