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Author

Rebecca Bohnert

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Open access Aug 2026

Long-read target enrichment sequencing for rAAV integration site analysis in engineered clones with targeted viral insertion

Together, the engineered clonal controls and optimized LR-TES provide reference material and a technical framework supporting rAAV ISA in safety evaluation, particularly when high structural resolution and specificity are needed to interpret predominant integration events.

Erica Coratella, Myriam Lemmens, Mevion Oertli et al. · 0 citations
Open access Jul 2026

SACF and GILA for in vitro transformation assessment of CRISPR/Cas9-edited cell therapy candidates: a multi-site study.

Data establish multi-site reproducibility of SACF and GILA in the MCF10A-PTPN12 model evaluated here and support their use as animal-free, development-stage characterization tools contributing to tumorigenicity evidence generation.

Lena Dorsheimer, J. Ferreira, Bojing Wang et al. · 0 citations

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