Sep 2026
Abstract PR008: EMT-associated focal adhesion signaling mediates resistance to RAS inhibition
Direct inhibition of oncogenic RAS has emerged as a clinically active therapeutic strategy for RAS-addicted cancers, including pancreatic ductal adenocarcinoma (PDAC). However, resistance is likely to limit the durability of therapeutic response, motivating combination strategies that target adaptive survival mechani...
Joshua H. Choe, Kyle J. Seamon, Julien Dilly et al.
· Cancer Research · 0 citations