Open access
Oct 2026
DZIP3 is a viral RNA co-sensor for RIG-I that promotes type-I interferon responses.
RNA-binding E3 ubiquitin ligases have the ability to link RNA regulation to the protein ubiquitination machinery, thereby influencing diverse biological processes. Here, we identify the RNA-binding E3 ubiquitin ligase DZIP3 as an innate immune sensor that couples viral RNA recognition to downstream immune signaling. Up...
Rinku Sahu, Soumya Kundu, Kollori Dhar et al.
· EMBO Journal · 0 citations