Author

Ranee Mehra

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Open access Sep 2026

Amivantamab plus pembrolizumab in previously untreated recurrent/metastatic head and neck squamous cell cancer: Results from the phase 1b/2 OrigAMI-4 study.

BACKGROUND Prognosis is poor for patients with recurrent/metastatic (R/M) head and neck squamous cell cancer (HNSCC), warranting novel treatments. Epidermal growth factor receptor (EGFR) and MET are overexpressed in HNSCC and contribute to cancer progression and metastasis. Amivantamab, an EGFR-MET bispecific antibody,...

Hsiang-Fong Kao, K. Harrington, A. Bhatia et al. · Clinical Cancer Research · 0 citations

Open access Sep 2026

PDS0101 With Pembrolizumab in HPV16-Positive Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma

Key Points Question Does adding PDS0101 to pembrolizumab demonstrate antitumor activity and tolerability in patients with recurrent/metastatic human papillomavirus type 16–positive head and neck squamous cell carcinoma who are immune checkpoint inhibitor (ICI)–naive or ICI-resistant? Findings In this nonrandomized clin...

Jared Weiss, J. Kaczmar, Ashish V. Chintakuntlawar et al. · JAMA Oncology · 1 citation

Open access Sep 2026

Tumor genomic alterations and their exploratory association with treatment response in recurrent head and neck cancer patients

While the genetic landscape of treatment-naïve head and neck squamous cell carcinoma (HNSCC) is well characterized, the molecular features of recurrent disease remain less defined. We investigated the genetic alterations in recurrent HNSCC and their associations with overall survival (OS), progression-free survival...

Olive Beyer, Andrey Loginov, D. Arons et al. · Scientific Reports · 0 citations