Author

Randall J. Roper

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Open access Sep 2026

Cognitive flexibility deficits differ between the sexes in a transchromosomic mouse model of Down syndrome.

Individuals with Down syndrome (DS) exhibit cognitive and behavioral phenotypes, including intellectual disability, and reduced cognitive flexibility. The TcMAC21 DS mouse model (Tc(HSA21,CAG-EGFP)1Yakaz/J) has a freely segregating human chromosome 21 containing ∼93% of protein-coding genes and was hypothesized to show...

Elysabeth Otte, Nicole Gordon, Andrew Folz et al. · Disease Models & Mechanisms · 0 citations

Open access Jul 2026

Sex-specific developmental phenotypes and their response to neonatal Dyrk1a reduction in the Ts65Dn Down syndrome mouse model

Dyrk1a normalization in Ts65Dn pups did not improve all abnormal phenotypes, perhaps because of developmental dysregulation between Dyrk1a RNA and DYRK1A protein levels, involvement of other trisomic genes, or improvements in only adult mice.

Alyssa Duerst, Laura E. Hawley, Linnea Johnson et al. · bioRxiv · 0 citations