Mutations That Matter: Domain-Specific Mutational Hotspots in BRCA1 and Its Key Interactors Differ Between TCGA and BCGA Breast Cancer Cohort—An In Silico Analysis
Differences in mutation patterns and positions in BRCA1 and its interacting partners contribute to variability in cancer manifestation and pathogenic burden, supporting the view that both mutation type and positional context shape pathogenic outcomes and highlight demographic variability in disease profiles.