Author

Ran Zhu

2 papers indexed here

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Open access Jul 2026

DPCGS: a computational framework for linking GWAS to single-cell transcriptomics in complex traits and diseases

DPCGS establishes a generalizable framework for dissecting the cellular architecture of complex traits and diseases, and enables systematic discovery of disease-relevant cell subpopulations, regulatory networks, and potential therapeutic targets, offering broad applications in human genetics, single-cell biology, and p...

Chonghui Liu, Bo Yuan, B. Shen et al. · bioRxiv · 0 citations

Open access Jul 2026

Targeting POLRMT-driven epigenetic remodeling of Wnt/β-catenin to eradicate colorectal cancer stem cell proliferation.

This work unveils POLRMT as a metabolic gatekeeper that licenses CSC plasticity through KDM6B-α-KG/H3K27me3-mediated chromatin remodeling, proposing the mitochondrial transcription machinery as a therapeutic target for dismantling the CSC hierarchy in CRC.

Lei Tang, Siheng Nie, Jia-Long Qi et al. · Cell Death and Differentiati... · 0 citations