Semi-synthesis of indole-fused taraxerone derivatives from Rhizophora stylosa Griff.: anti-bacterial study and docking insights.
A series of novel semisynthetic indole-fused taraxerone derivatives (2a-2f) were synthesised from taraxerone isolated from Rhizophora stylosa Griff. and characterised by 1H NMR,13C NMR, and HRMS analyses. Incorporation of the pharmacologically important indole moiety was aimed at enhancing protein-ligand interactions a...