Skeletal homeostasis depends critically on the local mechanobiological microenvironment. While well-known mechanosensitive ion channels like Piezo1 and Piezo2 translate physical forces into immediate membrane ion fluxes, the proximal sensors regulating medium- and long-term osteogenic pathways remain poorly understood....
Meghana Davuluri, Rekha Sathian, Anna R. Cho et al.· Mechanobiology in medicine· 0 citations
Over 90% of disease-associated variants from genome-wide association studies fall in noncoding regulatory regions, yet their functional interpretation remains a central open problem in genomic medicine. Large language models prompted to interpret such variants routinely hallucinate transcription factor (TF) binding cha...
P. Dutta, Matthew B. Obusan, Max Chao et al.· 0 citations
PGViS (Personal Genome Variant interpretation Score), a statistical framework that quantifies individual non-coding germline regulatory risk in non–small cell lung cancer (NSCLC), is presented, offering a cost-effective route to personal-genome risk assessment from germline variants alone.
Pallavi Surana, P. Dutta, Paolo Boffetta et al.· bioRxiv· 0 citations
It is shown that genome-wide enhancer annotations and candidate genetic variants predicted by DNABERT-Enhancer provide valuable resources for genome interpretation in functional and clinical genomics studies and can be explored interactively via the web application.
Rekha Sathian, P. Dutta, Ferhat Ay et al.· Bioinformatics· 0 citations
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