Aldosterone, the terminal effector of the renin-angiotensin-aldosterone system, regulates sodium retention, potassium excretion, and blood pressure. Beyond these classical effects, aldosterone-associated and mineralocorticoid receptor (MR)-mediated signaling is implicated in inflammation, oxidative stress, fibrosis, al...
Mehmet Kanbay, Rama Al-Shiab, Ermeena Shah et al.· Nephrology, Dialysis and Tra...· 0 citations
BACKGROUND AND AIMS
Sodium-glucose cotransporter-2 inhibitors (SGLT2is) improve cardiovascular and kidney outcomes, but their effects on circulating inflammatory biomarkers remain uncertain. We systematically reviewed randomized evidence on the effects of SGLT2is on peripheral-blood inflammatory biomarkers.
METHODS
P...
Mehmet Kanbay, Ermeena Shah, Rama Al-Shiab et al.· Diabetes, obesity and metabo...· 0 citations
Kidney imaging advances are transforming the field of nephrology by allowing non-invasive examination of renal structure, function, and pathology, and imaging biomarkers show significant predictive value for progression to kidney failure in CKD, including diabetic kidney disease, independent of traditional measurements...
Mustafa Guldan, Ibrahim Gulmaliyev, Rama Al-Shiab et al.· Clinical Kidney Journal· 0 citations
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