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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

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Raluca-Sînziana Zaharia

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Review Open access Oct 2026

Targeting Sirtuins in Neurodegenerative and Psychiatric Disorders: From Molecular Mechanisms to Pharmacological Modulation

Neurological and psychiatric disorders share several biological mechanisms, including mitochondrial dysfunction, oxidative stress, neuroinflammation, impaired protein homeostasis, and changes in synaptic plasticity. Sirtuins (SIRT) are nicotinamide adenine dinucleotide (NAD+)-dependent enzymes that regulate cellular me...

A. F. Păduraru, Raluca-Sînziana Zaharia, Iuliana Roată et al. · 0 citations

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