Author

Ralf J. Sommer

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Open access Sep 2026

A multifunctional PKS-NRPS megasynthetase in nematodes produces divergent signaling molecules that control different developmental arrests

To maximize their reproductive success, nematodes not only must arrest their development in response to adverse growth conditions but also must quickly recover if conditions improve. However, the molecular signals that coordinate these transitions remain poorly understood. Here, we show that a hybrid polyketide synthas...

Kevin Mai, Chi-Su Yoon, Dilip V. Prajapati et al. · Nature Communications · 0 citations

Open access Sep 2026

The logic of transgenerational inheritance in a nematode worm

Summary Epigenetic inheritance of environmentally induced phenotypes across generations has been observed in multiple taxa. However, the dynamics of non-genetic inheritance as a consequence of environmental variability remains poorly understood. Here, we take advantage of the transgenerational epigenetic inheritance (T...

Shiela Pearl Quiobe, A. Kalirad, Ralf J. Sommer · iScience · 0 citations

Open access Sep 2026

Terminal selector and subtype selector function across 200 million years of nematode evolution

The evolution of brains is subject to investigation in many different animal groups, each offering unique advantages to advance our understanding of the cellular, molecular and regulatory substrates of evolutionary change. Here, we use two nematode species, C. elegans and P. pacificus, separated by more than 200 millio...

Yasmin H. Ramadan, Curtis M. Loer, Hyunsoo Yim et al. · bioRxiv · 0 citations