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Sponsored AI Networking Cookbook: Practical recipes for AI-assisted network automation and development AI Networking Cookbook: Practical recipes for AI-assisted network automation and development

Author

Rajat Singh

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Open access Sep 2026

Cell-intrinsic functions of PD-L1 activate autophagy and prevent cytokine-induced apoptosis

Immune checkpoint inhibitor (ICI) therapy triggers complications that are currently attributed solely to immune activation. We hypothesized that target tissue–specific mechanisms also play a role and studied these mechanisms in thyrocytes. We found that thyroidal PD-L1 acts as a cytoprotective regulator, promoting cell...

Mihaela Stefan-Lifshitz, Nicola Viola, O. Meshcheryakova et al. · 0 citations
Open access Aug 2026

A programmable lipid-triggered allosteric site modulates LC3 LIR receptor binding activity

It is uncovered that membrane binding triggers a major conformational transition in LC3, exposing functional pockets that are occluded in its cytosolic form and can be engineered to precisely tune LC3-LIR interactions, offering a new strategy to regulate selective autophagy.

Deepanshi Gahlot, Jesu Castin, S. Mathur et al. · 0 citations

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