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Rajashekar Donaka

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Open access Sep 2026

Loss of SREBF1 disrupts lipid signaling and causes slow muscle fiber degeneration

Summary SREBF1, encoding the lipogenic transcription factor SREBP1, has been linked to lean mass by human genomics. We used a CRISPR-Cas9 srebf1 zebrafish knockout combined with LC-MS/MS lipidomics, RNA-seq, Lugol-enhanced micro-CT imaging, and functional assays. Srebp1 loss disrupted slow-fiber organization, increased...

Rajashekar Donaka, Kamal Awad, Iryna Khrystoforova et al. · 0 citations

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