Author

Rahul Kaushik

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Open access Sep 2026

Interpretable machine learning classifies β-lactamase subclasses and prioritizes boundary variants for antimicrobial resistance surveillance

Introduction Antimicrobial resistance is a major global health threat, and β-lactamase-mediated inactivation of β-lactam antibiotics remains a leading cause of treatment failure. Rapid identification of emerging β-lactamase variants and improved understanding of their functional diversity are therefore essential for re...

Rahul Kaushik, Suyong Re · Frontiers in Pharmacology · 0 citations

Review Open access Jul 2026

Intrinsically disordered regions as drivers of protein aggregation: mechanisms, phase separation, and emerging predictive frameworks

Findings support a unified framework in which sequence composition, conformational heterogeneity, and cellular environment cooperatively regulate functional assembly and pathological aggregation in intrinsically disordered proteins.

Rahul Kaushik, Suyong Re · Frontiers in Biophysics · 1 citation

Review Aug 2026

Computational navigation of constrained multidimensional protein fitness landscapes.

This review examines current computational strategies for exploring constrained protein fitness landscapes, including sequence-derived evolutionary descriptors, structural fitness assessment, energetic evaluation, and integrated multi-parameter scoring.

Rahul Kaushik, Firoozeh Piroozmand, Suyong Re · FEBS Letters · 0 citations